Do NOT use Motilium if:

• you are allergic to any ingredient in Motilium
• you are pregnant, planning to become pregnant, or become pregnant while taking Motilium
• you are breast-feeding.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motilium. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances.

Not to be used in

• Cancer of the pituitary gland resulting in over-production of the hormone prolactin (prolactinoma).
• Conditions in which stimulating movement through the stomach could be harmful, for example if there is bleeding, an abnormal hole (perforation) or a blockage in the stomach or intestines.
• Decreased liver function.

Some medicines may interact with Motilium. Tell your health care provider if you are taking any other medicines. The following medicines may oppose the stimulating effect of domperidone on the gut and so could make it less effective:

• antimuscarinic medicines, such as antispasmodics (eg atropine, hyoscine, propantheline), medicines for urinary incontinence (eg oxybutynin, flavoxate, tolterodine, propiverine, trospium), or antimuscarinics for Parkinson's (eg procyclidine, trihexyphenidyl, orphenadrine)
• strong opioid painkillers, eg morphine, codeine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motilium may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

• The safety of this medicine for use during pregnancy has not been established. It should not be used in pregnant women unless the potential benefits to the mother outweigh any risks to the developing baby. It should only be used if the medicine is considered essential by your doctor.  
• This medicine passes into breast milk in very small amounts that are not expected to be harmful to a nursing infant. However, the medicine is not recommended for use in women who are breastfeeding unless the potential benefit to the mother outweighs any risks to the nursing infant.

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Rare (affect between 1 in 1000 and 1 in 10,000 people)

• Increased level of prolactin (milk producing hormone) in the blood (hyperprolactinaemia). Sometimes this can lead to symptoms such as abnormal enlargement of breasts in men (gynaecomastia), abnormal production of breast milk in men and women, or stopping of menstrual periods in women.
• Decreased sex drive in men.

Very rare (affect less than 1 in 10,000 people)

• Stomach cramps.
• Diarrhoea.
• Itchy nettle-type rash (urticaria).
• Abnormal or uncontrolled movements of the hands, legs, face, eyes, neck or tongue, for example tremor, twitching or stiffness (extrapyramidal effects). Consult a doctor straight away if you notice any symptoms like this.
• Allergic reaction.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.